Most studies demonstrate a spontaneous miscarriage rate of 10-15%. However, the true rate of early pregnancy loss is close to 50% because of the high number of chemical pregnancies that are not recognized in the 2-4 weeks after conception. Most of these pregnancy failures are due to gamete failure (eg, sperm or oocyte dysfunction).
In internal medicine, the main causes for exam purposes are:
- Anticardiolipin Syndrome
- Lupus Anticoagulant (Anti-phospholipid)
- Fibrinogen Disorders
- Factor 13 deficiency