Takayasu’s disease

Inflammatory and stenotic disease of medium and large arteries with predilection for aortic arch
Subclavian artery -93%, common carotid -58%, aorta -47%
Affects adolescent girls and young women
Symptoms include arm claudication, Raynaud’s phenom., visual changes, TIA, HTN, renal failure, etc.
Prednisone (40-60 mg/day) alleviates symptoms (impact on survival is unclear).
Methotrexate is an alternative.
Aggressive surgical/angioplastic approach appears to improve survival.